To evaluate the association between time to dementia and baseline risk factors Lead Investigator: Lu Wang Institution : Michigan E-Mail : luwang@umich.edu Proposal ID : 100 Proposal Description: In this project, we will explore the following three approaches to analyze the data. 1. Grouped survival analysis, by treating the visit time as fixed annually. 2. Develop a likelihood method for interval censored time to dementia, where both the observed censored intervals and the number of intervals are random. 3. Develop a methodology to account for missing covariates, including both baseline variables and time dependent variables. We will develop the weighted estimating methods and will target on some double-robust estimators as well.